Ion Selectivity in Acid-Sensing Ion Channels and Epithelial Sodium Channels
نویسندگان
چکیده
منابع مشابه
Acid-Sensing Ion Channels
Acetylcholine is a neurotransmitter synthesized from choline and acetyl coenzyme A. It is localized in large reticular formation neurons, and is the chemical mediator in the synapse of a motor endplate. The electrical signal of the motor nerve terminal causes release of many packets of acetylcholine. The packets are released into the synaptic cleft, where receptors in the postjunctional membran...
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The ASIC channels constitute a subfamily within the larger ENaC superfamily. Despite the fact that the ASICs share only about 20-25% identity with the ENaC channels they display all the characteristics of the superfamily, which are, two transmembrane spanning domains, a large extracellular domain and short intracellular N and C termini. The functional channel of the superfamily is composed of 4...
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Pathophysiological conditions such as inflammation, ischemia, infection and tissue injury can all evoke pain, and each is accompanied by local acidosis. Acid sensing ion channels (ASICs) are proton-gated cation channels expressed in both central and peripheral nervous systems. Increasing evidence suggests that ASICs represent essential sensors for tissue acidosis-related pain. This review provi...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2018
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2017.11.179